High Latency and IPv6 dropped randomly

DNSCrypt-proxy had an issue last night, router logs indicate DoH suddenly could not resolve and when it came back my latency skyrocketed. Everything was working fine from inital setup about a week ago until last night. Several router reboots did not solve the issue. IPv6 also appears to have issues finding ultra low latency servers:

https://nextdns.io/diag/4ef59920-bf97-11ef-b908-f7ea0cef028c